Determining the Best Immunization Strategy for Protecting African Children Against Invasive Salmonella Disease

Vaccines against invasive Salmonella disease

Serovars of the Gram-negative bacterium Salmonella enterica are usually associated with food-borne diarrheal illness in high-income countries. Such gastrointestinal disease is normally self-limiting and rarely life-threatening. Perhaps surprisingly, Salmonella has not been identified as a principal etiological agent of diarrhea in developing countries. 1 Nevertheless, Salmonellae are responsibl...

Antibodies and Protection Against Invasive Salmonella Disease

Invasive disease caused by Salmonella enterica is a major global public health concern. It has two main clinical forms: enteric fever and invasive nontyphoidal Salmonella (iNTS) disease. Enteric fever imposes its highest burden of disease in South and South-East Asia and is principally caused by S. Typhi and S. Paratyphi A. Conversely, iNTS disease is a particular problem in subSaharan Africa w...

Recent Advances in Immunization of Horses Against African Horsesickness

Cytokine Profiles during Invasive Nontyphoidal Salmonella Disease Predict Outcome in African Children

Nontyphoidal Salmonella is a leading cause of sepsis in African children. Cytokine responses are central to the pathophysiology of sepsis and predict sepsis outcome in other settings. In this study, we investigated cytokine responses to invasive nontyphoidal Salmonella (iNTS) disease in Malawian children. We determined serum concentrations of 48 cytokines with multiplexed immunoassays in Malawi...

recent advances in immunization of horses against african horsesickness

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